In Silico Analysis of Plant-Based Bioactive Compounds Targeting Progesterone Receptors for the Treatment of Uterine Leiomyoma

Uterine leiomyomas are the most common benign gynaecological tumours that affect 50% - 60% of females belonging to reproductive age. The role progesterone in growth and development is evident. Progesterone regulated by receptors it acts activating PI3K/AKT pathway, increasing proliferating cell nuclear antigen (PCNA) levels Bcl-2 expression. Thus, modulating receptor can help treatment leiomyomas. current study involves testing efficiency various plant-based bioactive compounds bind receptors, which may possess inhibitory or modulatory effects on against receptors. These be further experimented with using other vivo vitro methods produce phytomedicine based drugs for uterine This an silico analysis performed bioinformatics databases software. ligand structures were retrieved from PDB PubChem databases. Their pharmacokinetics pharmacodynamics properties analyzed AutoDock4.2.6 was used molecular docking, results visualized LigPlot+. Among 15 selected, 8 had higher binding energies than control drug Ulipristal acetate i.e., -8.21Kcal/mol. Of Ursolic acid, Vitamin-D2, Betulinic acid above -9.0 Kcal/mol. concludes these modulate thus decreasing proliferation Further studies bring out potential therapeutic they act as a lead compound design novel targets leiomyoma.